Linmesa lamet so African Swine Fever ed South Korea kayari na taloy bulan

Nen imbeneg a Simba, sakey a panagpastolan na baboy ed South Korea ya walaan na 2,400 a baboy so angikumpirma na insabi na African Swine Fever (ASF). Taloy bulan labat kayari na sankabaloan ya kumpirmadon kaso nen Mayo 4, say bansa et walad atagey ya alerto pian nakontrol so ikayat na sayan makapatey ya virus. (Say agano nin inmabig et lapud saray ogogaw ya baboy ya nianak ed primabera et mas aktibo ed tiagew. Say virus et aktibo ed Europe tan Asia, tan nalmoan ya kinmayat ed South America nen apalabas iran bulan)

Unong ed Korea Herald, say ASF working group ya idadaulo na gobierno so angi-anunsyo ya saray kaso na ASF so akumpirma ed sakey a panagpastolan na baboy diad Goseong County, Gangwon Province. Sayan farm so saksakey ya farm na baboy ed loob na taloran kilometro. Walay duaran uma ya walad loob na 10 kilometro ya walay dagup ya 3,100 ya baboy.

Diad kaplesan, manlapu nen inmaligwas so sakit nen Setyembre 2019, say South Korea et akakumpirma na 18 kaso na ASF diad saray lokal ya panag-alaan na baboy. Pinatey na saray autoridad so masulok ya 450,000 ya baboy manlapud 14 ya panag-alaan na baboy ed loob na inmunan 30 ya agew. Kaiba iray atap ya baboy, walay dagup ya 1,517 ya kaso na African swine fever so adiskobre.

Anggapo ni so bakuna parad ASF natan. Manlapu nen inmaligwas so sakit ed Vietnam, in-anunsyo to met ya nasumpal toy panagsukimat ed bakuna diad ontumbok ya duaran taon, tan wala met iray report ed Pilipinas ya iilaloan ton mangilunsad na bakuna na ASFV diad sampot na Agosto ed sayan taon. Anggano antoy online propaganda, nepeg ya malinew so kanonotan tayo ya walay makatunongan ya panmoria ed posibilidad na bakuna na ASFV. Saray maaligwas a bansa et pigaran dekada lan manggagawa na bakuna parad ASFV, balet ta ag ni ra tinmalona. Konserbatibo so pangibaga ya anggapo lay ASFV ya bakuna ed tindaan diad ontumbok ya 10 taon. Akin et ibabaga tayon walay koneksion to ed saray katangian na sayan ASFV.

Say impamawala na nanduruman klase na bakuna et nantutumbokan ya ag tinmalona

1. Ag-aktibo so bakuna

Anggaman saray eksperimento et makapawala na high-titer ya antibodies kayari na panagbakuna, balanglan cell-cultured ASFV odino inactivated ya bakuna, anggapoy epektibon proteksion to. Saray antibodies ya nagawa kayari na immunization et makapangibawas labat na virus titer, balet ag da sigpot ya na-neutralize so virus. Anggan say serum na baboy ya ag-onkukurang ed baboy et agto na-neutralize so ASFV. Labay ton ibaga, say bakuna et makapawala na antibodies, balet say virus et ag-onkiwas no onsabi itan. Ag-asumpal so impamawala na saray bakuna ya ag-onkikiwas.

2. Pinakapuy so bakuna

Say ASFV et nayarin naandi kayari na dakel a panaon, tan saray baboy ya abakunaan na saray attenuated strain et makapawala labat na pigaran grado na immune protection sumpad homologous virulent strains. Balet, legan ya ondarakel so pasahe, legan ya onbabawas so pathogenicity, onbabawas met so immunogenicity.

Diad arum a salita, saray antibodies ya ginawa na attenuated vaccine et epektibo labat ed sakey a strain. Say manunan punto et saray batch na virus ya in-subculture ed onian paraan et aliwan balido.

Walay mas seryoson problema. Kayari na panagbakuna na saray attenuated vaccines, nayarin pansengegan na pirmin impeksion ed 25-50% na saray baboy. Saya so sakey a trahedya, lapud saray mabunigas a baboy et direktan naimpektaan kayari na panagbakuna.

Siopay agmalabay ya saray mabunigas a baboy to et naimpektaan na non-pest virus? Kanian ag tinmalona so pinakapuy ya bakuna.

3. Bakuna ya pangekal na gene

Diad teorya, no ikompara ed tradisyonal iran bakuna ya walay gene-deleted ya bakuna et mas baleg so bentaha to ed pamaaligwas na kaligenan tan inkaepektibo. Saray ASFV virulence genes tan saray genes ya misiglaotan ed host range- et naimano la. Saray attenuated strains ya anggapoy thymidine kinase gene tan dakel a membro na multi-gene family et makaresisti ed saray homologous virulent attacks.

Balet, say immune effect na saray attenuated strains ya sengegan na gene deletion et mandedepende met ed strain-. Sakey ni, lapud say genome na African swine fever virus et komplikado, walaan itan na anggad 12 ya immune evasion genes. No dinan a gene so nayarin naekal so nayarin mamalemew ed virus. Say toxicity ya ag makaapekto ed immunogenicity so pokus tan kairapan na kaplesan ya panagsukimat. Niarum ni, saray kaplesan ya gagawaen ya live attenuated vaccines et ag ni sigpot ya attenuate, tan wala ray mapatnag ya epekto kayari na immunization lapud virus. Sakey ni, say kondisyon na produksyon na saray bakuna ya ag-onkupas et medyo atagey. Niarum ni, mairap met so mananap na matukoy a baleg a produksyon na saray linya na selula. .

Diad arum a salita, say gene deletion vaccine et apektado na strain dependence, saray katangian na baleg a genome, saray makapuy ya epekto, tan say passage cell line, tan say gene deletion vaccine et ag tinmalona.

4. Subunit ya bakuna

Say bentaha na subunit vaccine et talagan ligtas, tan sarag ton ibiig so vaccine virus tan antibody ya ginawa na wild virus. Balet, dakel so klase na structural proteins ya in-encode na African swine fever virus, tan mairap ya nadampot so sankaabigan ya immune effect no mandepende labat ed sakey odino pigaran protina.

Nalmoan ed saray impanaral ya saray ASFV neutralizing antibodies et akaarap ed taloran viral proteins, p30, p54 tan p72 . Say pankakasakey ya panagbakuna ed p30 tan p54 et makapangiter labat na manga 50% ya proteksion. Say CD2v protein na 80 tan 81 ASFV et makapangiter labat na partial a proteksion.

Kanian, lapud nanduruman klase na protina tan makapuy ya proteksion, ag-asumpal so subunit vaccine.

5. DNA ya bakuna

Inkonekta na saray researcher so p54 tan p30 genes ed ginawan plasmid pCMV-PQ pian nipatnag so soluble p30 tan p54 ya protina, balet say DNA ya bakuna ya ginawa ed sayan paraan et ag akagamor na makapenek ya proteksion ed immune kayari na impanbakuna ed saray baboy. Say mas maabig ya punto et say pangisulong ed saray abakunaan ya baboy, tan saray akaliktar ya baboy et anggapoy detoxification phenomenon da.

Lapud proteksion na bakuna na DNA ya abeba so epekto to, ag tinmalona iray bakuna na DNA.

Say posibilidad na arapen

Diad kaplesan, saray subunit vaccines tan DNA vaccines so pokus na panagsukimat tan panagpaalagey. Anggaman ag ira makapangiter na mabiskeg a proteksion, lapud saray abitlan problema ed tagey et sakey-sakey ya natalonaan, wala ni so ilalo ya makagawa na bakuna ya mas atagey so proteksion to. Diad kaplesan, say Estados Unidos tan pigaran bansa et mantutultuloy nin manaral.

Diad saman met a panaon, say iyaaligwas na panagsukimat ed bakuna ed African swine fever virus et ag nagawaan ed sakey a labi, tan wala ni so andukey a dalanen antis ya nilako so tuan bakuna ed African swine fever.

Nensaman, say immature gene-deficient ya bakuna so inlunsad ed tindaan, ya sengegan na inkayat na virus, ya atagey so proteksion tan atagey ya mortality rate, tan tuloytuloy ya onkakayat ed pabitay tan pabitay diad pasen. Diad kasunian, saya so sengegan na baleg a salot ed industriya na baboy ed bansa mi, tan saya so mangaapekta ni ed dakel a uma, lalo la ed angkakabaleg iran uma. No naala la ra, mairap lan maong ya linisan ira, kanian baleg so pakalukpos da ed ekonomya. Say kaplesan ya non- ya prebension tan panangontrol ed salot et nibase ni ed biosecurity. Say panggawa na nakaukolan ya prebension tan panangontrol ed sistema so paraan pian naprebentaan iray aliwan -faults natan.